The use of psychedelics, such as psilocybin and LSD, is being explored as a potential therapy for mental health disorders. These substances, along with atypical psychedelics like ketamine and MDMA, are showing promise in treating conditions like depression, anxiety, and PTSD. However, transitioning from clinical trials to regular practice poses challenges. Psychedelics are typically used in conjunction with therapy, and it’s important to assess the effectiveness of the accompanying therapy. Safety measures must be in place to prevent potential abuse or boundary transgressions. Professional training, regulatory oversight, and informed consent procedures are essential. Collaborative efforts involving healthcare professionals, regulatory bodies, policymakers, and patients are needed. Preemptive regulatory measures are being taken in countries like Portugal to address potential challenges. It’s crucial to inform the public about psychedelic therapies and manage expectations. Many aspects, including dosages, treatment settings, and accessibility, still need to be determined. Conducting unbiased studies is challenging due to the psychoactive effects of psychedelics. Flexibility and adaptability in guidelines and regulations are necessary as our understanding of these therapies evolves. A uniform framework is needed to ensure consistent and safe practices. The ethical and regulatory aspects of psychedelic treatments require careful consideration.